Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer–Soft Tissue and Bone Sarcoma Group (EORTC–STBSG) recommendations for pathological examination and reporting. (January 2016)

• Record Type: Journal Article
• Authors: Wardelmann, E.; Haas, R.L.; Bovée, J.V.M.G.; Terrier, Ph; Lazar, A.; Messiou, C.; LePechoux, C.; Hartmann, W.; Collin, F.; Fisher, C.; Mechtersheimer, G.; DeiTos, A.P.; Stacchiotti, S.; Jones, R.L.; Gronchi, A.; Bonvalot, S.
• Is Part Of: European journal of cancer. Volume 53(2016)
• Page Start: 84
• Page End: 95
• Publication Date: 2016-01
• Subjects: Soft tissue sarcoma -- Radiotherapy -- Chemotherapy -- Response evaluation -- Pathology -- Guideline; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2015.09.021
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: At present, there is not a commonly used and generally accepted standardized approach for the pathologic evaluation of pretreated soft tissue sarcomas. Also, it is still unclear whether the cut-off for prognostic relevance is similar in the many different histological subtypes of STS. This manuscript, produced by a European Organization for Research and Treatment of Cancer – Soft Tissue and Bone Sarcoma Group (EORTC–STBSG) endorsed task force, aims to propose standardization of the pathological examination process and the reporting of STS resection specimens after neoadjuvant radio- and/or chemotherapy. Highlights: At present, no standardized pathologic evaluation criteria of soft tissue sarcomas (STS) exist. Also, it is unclear whether the cut-off for prognostic relevance is similar among STS subtypes. Here, the EORTC–STBSG proposes a standardization of the pathological examination process. This manuscript focuses on reporting of STS resection specimens after neoadjuvant therapy.