Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb). (February 2016)

• Record Type: Journal Article
• Authors: Saghiri, Mohammad Ali; Orangi, Jafar; Asatourian, Armen; Sorenson, Christine M.; Sheibani, Nader
• Is Part Of: Critical reviews in oncology/hematology. Volume 98(2016)
• Page Start: 290
• Page End: 301
• Publication Date: 2016-02
• Subjects: As arsenic -- FGF-2 basic fibroblast growth factor -- BMP-2 bone morphogenetic protein-2 -- Ce cerium -- COX cyclooxygenase -- EC endothelial cells -- EPCR endothelial cell protein C receptor -- EPCs endothelial progenitor cells -- EMT epithelial to mesenchymal transition -- ERK extracellular signal regulated kinase -- HUVEC human umbilical vein endothelial cells -- HIF hypoxia-inducible factor -- IAP inhibitor-of-apoptosis protein -- IL interleukin -- GSK glycogen synthase kinase -- Pb lead -- Li lithium -- MMP matrix metalloproteinase -- Hg mercury -- MeHg methylmercury -- MAPK mitogen activated protein kinase -- Nb niobium -- NO nitric oxide -- NF-κB nuclear factor-κB -- PI3K phosphatydil inositol 3-kinase -- ROS reactive oxygen species -- rhVEGF recombinant human VEGF -- S1P1 sphingosine-1-phosphate type 1 receptor -- TM thrombomodulin -- Ti titanium -- TiO2 titanium dioxide -- TGF transforming growth factor -- TNF tumor necrosis factor -- Va vanadium -- VEGF vascular endothelial growth factor -- VEGFR VEGF receptor -- vWF von Willebrand factor -- ZEB zinc finger E-box-binding homeobox; Angiogenesis -- Endothelial cells -- Inorganic elements; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2015.10.004
• Languages: English
• ISSNs: 1040-8428

Abstract

Highlights: Ti surfaces with different topographies and hydrophilicities mediate different cellular responses. The anti-angiogenic effect of TiO2 nanoparticles comes from the inhibition of angiogenic processes, and not from cytotoxicity. Li affects vasculogenesis but not angiogenesis, supporting the hypothesis that these processes are differently regulated. Arsenic has the dual effects on vascular cells and tumor angiogenesis, at low dose promotes, while at high dose inhibits angiogenesis. Lead exposure induced IL-8 production and promotes tumor growth and invasion via inducing angiogenesis. Abstract: Many essential elements exist in nature with significant influence on human health. Angiogenesis is vital in developmental, repair, and regenerative processes, and its aberrant regulation contributes to pathogenesis of many diseases including cancer. Thus, it is of great importance to explore the role of these elements in such a vital process. This is third in a series of reviews that serve as an overview of the role of inorganic elements in regulation of angiogenesis and vascular function. Here we will review the roles of titanium, lithium, cerium, arsenic, mercury, vanadium, niobium, and lead in these processes. The roles of other inorganic elements in angiogenesis were discussed in part I (N, Fe, Se, P, Au, and Ca) and part II (Cr, Si, Zn, Cu, and S) of these series. The methods of exposure, structure, mechanisms, and potential activities of these elements are briefly discussed. An electronic search was performed on the role of these elements in angiogenesis from January 2005 to April 2014. These elements can promote and/or inhibit angiogenesis through different mechanisms. The anti-angiogenic effect of titanium dioxide nanoparticles comes from the inhibition of angiogenic processes, and not from its toxicity. Lithium affects vasculogenesis but not angiogenesis. Nanoceria treatment inhibited tumor growth by inhibiting angiogenesis. Vanadium treatment inhibited cell proliferation and induced cytotoxic effects through interactions with DNA. The negative impact of mercury on endothelial cell migration and tube formation activities was dose and time dependent. Lead induced IL-8 production, which is known to promote tumor angiogenesis. Thus, understanding the impact of these elements on angiogenesis will help in development of new modalities to modulate angiogenesis under various conditions.