Vaccine Adjuvants: Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles (Small 12/2016). Issue 12 (March 2016)

• Record Type: Journal Article
• Authors: Chen, Weiyu; Zhang, Bing; Mahony, Timothy; Gu, Wenyi; Rolfe, Barbara; Xu, Zhi Ping
• Is Part Of: Small. Volume 12:Issue 12(2016)
• Page Start: 1541
• Page End: 1541
• Publication Date: 2016-03
• Subjects: clay nanoparticles -- hectorite -- intimin β -- layered double hydroxides -- vaccine adjuvants; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201670058
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : On page 1627, layered double hydroxide (hexagonal) and hectorite (sheet) nanoparticles are demonstrated to be promising vaccine adjuvants by T. Mahony, Z. P. Xu, and co‐workers. The nanoparticles induce sustained, high levels of specific antibodies (IgG and IgA) and a strong cell‐mediated response (IFN‐γ), in comparison with the commonly‐used adjuvant QuilA. Their high adjuvanticity could be attributed to the high antigen loading, facilitation to the antigen cellular uptake and the depot effect.