PEGylation of Chitosan Via Nitroxide‐Mediated Polymerization in Aqueous Media. Issue 1 (9th October 2015)

• Record Type: Journal Article
• Authors: Darabi, Ali; García‐Valdez, Omar; Champagne, Pascale; Cunningham, Michael F.
• Other Names: Paulis María guestEditor.; Asua José M. guestEditor.
• Is Part Of: Macromolecular reaction engineering. Volume 10:Issue 1(2016)
• Page Start: 82
• Page End: 89
• Publication Date: 2015-10-09
• Subjects: chitosan -- nitroxide‐mediated polymerization -- PEGylation; Polymers -- Periodicals; Polymerization -- Periodicals; Reaction mechanisms (Chemistry) -- Periodicals; Electronic journals; 547.705
• DOI: 10.1002/mren.201500024
• Languages: English
• ISSNs: 1862-832X

Abstract

Abstract : The PEGlytation of CTS with poly(poly(ethyleneglycol) methyl ether methacrylate‐co‐styrene), poly(PEGMA‐co‐S), via nitroxide‐mediated polymerization (NMP) using both grafting to and from approaches has been performed. To conduct the PEGylation of CTS via grafting to, CTS was first functionalized with glycidyl methacrylate (GMA) yielding CTS‐ g ‐GMA macromer. Poly(PEGMA‐co‐S), synthesized via NMP, was then grafted to the CTS‐ g ‐GMA. For PEGylation via grafting from, CTS‐ g ‐GMA was first converted into a macroalkoxyamine using an SG1‐based alkoxyamine. Graft copolymerization of PEGMA‐co‐S was then performed. The syntheses of CTS‐ g ‐GMA‐poly(PEGMA‐co‐S) were confirmed by 1 H NMR and TGA. Abstract : The PEGylation of chitosan with well‐defined PEGMA‐based copolymers via NMP is presented. The PEGylation is achieved using grafting to and from approaches performed in aqueous media avoiding the use of organic solvents, while preserving the amino group of chitosan, features that are attractive for potential applications of the final materials.