Copper(ii)-catalyzed C5 and C7 halogenation of quinolines using sodium halides under mild conditions. Issue 11 (18th February 2016)

• Record Type: Journal Article
• Authors: Xu, Jun; Zhu, Xiaolei; Zhou, Guobin; Ying, Beibei; Ye, Pingping; Su, Lingying; Shen, Chao; Zhang, Pengfei
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 11(2016)
• Page Start: 3016
• Page End: 3021
• Publication Date: 2016-02-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob00169f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A simple and mild protocol for copper catalyzed halogenation of quinoline at C5 and C7 positions was developed, affording the desired remote C–H activation products in moderate to good yields. Abstract : A simple and mild protocol for copper catalyzed halogenation of quinoline at C5 and C7 positions was developed, affording the desired remote C–H activation products in moderate to good yields. This reaction proceeds with low-cost sodium halides (NaX, X = Cl, Br, I) and features excellent substrate tolerance. A series of control experiments were carried out to illustrate a single-electron-transfer process which plays a vital role in the halogenation.