PdII/CuBr2 catalysed keto α-Csp3–H benzoxylation of N, N-dialkylamides directed by o-hydroxy groups. Issue 24 (2nd March 2016)

• Record Type: Journal Article
• Authors: Santra, Sourav Kumar; Banerjee, Arghya; Rajamanickam, Suresh; Khatun, Nilufa; Patel, Bhisma K.
• Is Part Of: Chemical communications. Volume 52:Issue 24(2016)
• Page Start: 4501
• Page End: 4504
• Publication Date: 2016-03-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc00971a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A hydroxy group directed keto α-Csp3 –H benzoxylation of N, N -dialkylamides has been accomplished with a Pd(ii )/CuBr2 catalytic combination. Abstract : A hydroxy group directed keto α-Csp3 –H benzoxylation of amides, including N, N -dialkylamides and cyclic amides, has been accomplished involving ortho -hydroxy substrates possessing either an aldehydic or a keto methyl (–COCH3 ) group with a Pd(ii )/CuBr2 catalytic combination. The carboxy group obtained via the in situ oxidation of –CHO or –COCH3 groups of ortho -hydroxy substrates then undergoes a cross-dehydrogenative coupling (CDC) with amides to furnish an α-benzoxylation product with concurrent aromatic ring bromination.