Enantioselective total synthesis and structural reassignment of (+)-alsmaphorazine E via a traceless chirality transfer strategy. Issue 24 (2nd March 2016)

• Record Type: Journal Article
• Authors: Yu, Kuan; Gao, Beiling; Liu, Zhaobo; Ding, Hanfeng
• Is Part Of: Chemical communications. Volume 52:Issue 24(2016)
• Page Start: 4485
• Page End: 4488
• Publication Date: 2016-03-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc00930a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The first enantioselective total synthesis of (+)-alsmaphorazine E was described, which led to the structural reassignment of the title molecule. Abstract : The first enantioselective total synthesis of (+)-alsmaphorazine E has been achieved through a traceless chirality transfer strategy, which also enabled structural reassignment of the natural product. Key features of this efficient approach entail a catalytic intramolecular oxidative cyclization, a diastereoselective oxidative cyclic aminal formation and a radical cyclization/transannular aza-Michael addition cascade.