DNA base-stacking assay utilizing catalytic hairpin assembly-induced gold nanoparticle aggregation for colorimetric protein sensing. Issue 22 (24th February 2016)

• Record Type: Journal Article
• Authors: Chang, Chia-Chen; Chen, Chie-Pein; Chen, Chen-Yu; Lin, Chii-Wann
• Is Part Of: Chemical communications. Volume 52:Issue 22(2016)
• Page Start: 4167
• Page End: 4170
• Publication Date: 2016-02-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc01238h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A label-free and enzyme-free colorimetric sensing platform for the amplified detection of fibronectin was developed based on an ingenious combination of catalytic hairpin assembly and a base stacking hybridization-based gold nanoparticle aggregation strategy. Abstract : A label-free and enzyme-free colorimetric sensing platform for the amplified detection of fibronectin was developed based on an ingenious combination of catalytic hairpin assembly and a base stacking hybridization-based gold nanoparticle aggregation strategy. The detection limit of 2.3 pM is at least one order of magnitude lower than that of established fibronectin biosensors.