Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry. Issue 23 (1st March 2016)

• Record Type: Journal Article
• Authors: Hinneburg, H.; Hofmann, J.; Struwe, W. B.; Thader, A.; Altmann, F.; Varón Silva, D.; Seeberger, P. H.; Pagel, K.; Kolarich, D.
• Is Part Of: Chemical communications. Volume 52:Issue 23(2016)
• Page Start: 4381
• Page End: 4384
• Publication Date: 2016-03-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc01114d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Abstract : Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N -acetylneuraminic acid linkages of N -glycans can be identified in a site-specific manner from individual glycopeptides using ion mobility-mass spectrometry analysis of diagnostic fragment ions.