Regioselective iodoamination of terminal ynamides for the synthesis of α-amino-β, β-diiodo-enamides. Issue 23 (26th February 2016)

• Record Type: Journal Article
• Authors: Huang, Hai; Tang, Luning; Han, Xiaobo; He, Guangke; Xi, Yang; Zhu, Hongjun
• Is Part Of: Chemical communications. Volume 52:Issue 23(2016)
• Page Start: 4321
• Page End: 4324
• Publication Date: 2016-02-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc00370b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We developed the intermolecular iodoamination of terminal ynamides for the synthesis of α-amino-β, β-diiodo-enamides. Abstract : A mild and efficient methodology involving the I2 /TBHP-mediated intermolecular iodoamination of ynamides with amines for the synthesis of α-amino-β, β-diiodo-enamides was developed. This reaction provides the first intermolecular iodoamination of terminal alkynes to diiodo-enamines and can be easily applied to a wide range of substrates.