Inertial focusing in non-rectangular cross-section microchannels and manipulation of accessible focusing positions. Issue 6 (8th February 2016)

• Record Type: Journal Article
• Authors: Kim, J.; Lee, J.; Wu, C.; Nam, S.; Di Carlo, D.; Lee, W.
• Is Part Of: Lab on a chip. Volume 16:Issue 6(2016)
• Page Start: 992
• Page End: 1001
• Publication Date: 2016-02-08
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c5lc01100k
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : We studied inertial focusing in non-rectangular channels and presented a method for particle manipulation by connection of various cross-section channels. Abstract : Inertial focusing in microfluidic channels has been extensively studied experimentally and theoretically, which has led to various applications including microfluidic separation and enrichment of cells. Inertial lift forces are strongly dependent on the flow velocity profile and the channel cross-sectional shape. However, the channel cross-sections studied have been limited to circles and rectangles. We studied inertial focusing in non-rectangular cross-section channels to manipulate the flow profile and thus the inertial focusing of microparticles. The location and number of focusing positions are analyzed with varying cross-sectional shapes and Reynolds number. We found that the broken symmetry of non-equilateral triangular channels leads to the shifting of focusing positions with varying Reynolds number. Non-rectangular channels have unique mapping of the focusing positions and the corresponding basins of attraction. By connecting channels with different cross-sectional shapes, we were able to manipulate the accessible focusing positions and achieve focusing of microparticles to a single stream with ∼99% purity.