Bifunctional tertiary amine-squaramide catalyzed asymmetric catalytic 1, 6-conjugate addition/aromatization of para-quinone methides with oxindoles. Issue 22 (24th February 2016)

• Record Type: Journal Article
• Authors: Deng, Yu-Hua; Zhang, Xiang-Zhi; Yu, Ke-Yin; Yan, Xu; Du, Ji-Yuan; Huang, Hanmin; Fan, Chun-An
• Is Part Of: Chemical communications. Volume 52:Issue 22(2016)
• Page Start: 4183
• Page End: 4186
• Publication Date: 2016-02-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc10502a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel organocatalytic enantioselective 1, 6-addition of p -QMs has been developed to access diarylmethine-functionalized oxindoles bearing vicinal tertiary and quaternary stereocenters. Abstract : The asymmetric catalytic 1, 6-addition of p -QMs with racemic oxindoles under the bifunctional catalysis of C 2 -symmetric dimeric Cinchona -derived squaramide is described. This tertiary amine-squaramide catalyzed reaction provides a diastereoselective and enantioselective approach to the effective assembly of diverse diarylmethine-substituted oxindoles having vicinal tertiary and quaternary stereocenters.