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Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(iii) complex as correlative label. Issue 23 (29th February 2016)
Record Type:
Journal Article
Title:
Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(iii) complex as correlative label. Issue 23 (29th February 2016)
Main Title:
Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(iii) complex as correlative label
Abstract : We present the synthesis of polylactide by ring-opening polymerization using a luminescent iridium(iii ) complex acting as initiator. Abstract : We present the synthesis of polylactide by ring-opening polymerization using a luminescent iridium(iii ) complex acting as initiator. The polymer was formulated into nanoparticles, which were taken up by HEK-293 cells. We could show that the particles provided an appropriate contrast in both superresolution fluorescence and electron microscopy, and, moreover, are non-toxic, in contrast to the free iridium complex.