Maternal and fetal HLA-G 14 bp gene polymorphism in pregnancy-induced hypertension, preeclampsia, intrauterine growth restricted and normal pregnancies. (2nd May 2016)

• Record Type: Journal Article
• Authors: Mandò, Chiara; Pileri, Paola; Mazzocco, Martina I.; Lattuada, Debora; Zolin, Anna; Plebani, Maddalena; Massari, Maddalena; Calabrese, Stefania; Milani, Silvano; Cetin, Irene
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 9(2016)
• Page Start: 1509
• Page End: 1514
• Publication Date: 2016-05-02
• Subjects: Feto-maternal immune tolerance -- genetic risk -- obstetrical complications -- pregnancy pathology -- successful placentation; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2015.1052398
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : Trophoblast expression of Human Leukocyte Antigene-G (HLA-G) is essential for feto-maternal immune tolerance and successful placentation. There is contradicting evidence on the relationship between HLA-G polymorphisms and preeclampsia (PE), intrauterine growth restriction (IUGR) and pregnancy-induced hypertension (PIH). Here, we investigate the association between both maternal and fetal HLA-G 14 bp insertion/deletion polymorphism and obstetrical complications. Methods : Clinical and genetic data of 282 women/fetuses (31 severe PE, 8 mild PE, 46 IUGR, 42 PIH and 155 controls) were analyzed both individually and jointly under a codominant, a dominant and a recessive model. Results : HLA-G 14 bp polymorphism was not associated with obstetrical complications, considering the mother and fetus genotypes both jointly and individually. Conclusions : With this study we filled several gaps occurring in previous studies: we analyzed a very well-defined population of PE, PIH and IUGR pregnancies, considering both fetal and maternal HLA-G 14 bp polymorphism, individually and jointly. Our findings showed that fetal and maternal HLA-G 14 bp genotypes are not associated with increased risk for the development of obstetrical complications, suggesting that this polymorphism has no immuno-modulatory role in the development of PE, PIH or IUGR.