Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women. (17th February 2016)

• Record Type: Journal Article
• Authors: Irge, Emine; Halici, Zekai; Yilmaz, Mehmet; Cadirci, Elif; Karakus, Emre
• Is Part Of: Clinical and experimental hypertension. Volume 38:Number 2(2016)
• Page Start: 189
• Page End: 193
• Publication Date: 2016-02-17
• Subjects: 5-HT -- 5-HT7 receptor -- placenta -- pre-eclampsia; Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.3109/10641963.2015.1081215
• Languages: English
• ISSNs: 1064-1963

Abstract

Abstract: In this study, by examining 5-HT7 receptor expression in placentae from pre-eclamptic and normal pregnancies, we aimed to discover a new step of pathophysiological cascade for preeclampsia. Patients whose blood pressure over the 140/90 mmHg were included when study after 20 weeks of gestation. 5-HT7 receptor expression was investigated on the placentae obtained after birth by real time PCR (RT-PCR) analysis. Pre-natal–post-natal, systolic–diastolic blood pressure values, proteinuria and renal function indicators as BUN and creatinine levels of pre-eclamptic pregnant women were higher than the healthy group. Similarly, 5-HT7 receptor expression determined in healthy placentae increased 8-fold in pre-eclamptic women. This study, for the first time we showed 5-HT7 receptor expression in normal placenta and increased expression in pre-eclamptic placenta.