Diagnostic clues for FNA diagnosis of intranodal palisaded myofibroblastoma, a rare benign lesion, an introspective case report. Issue 4 (22nd January 2016)

• Record Type: Journal Article
• Authors: Sood, Neelam
• Is Part Of: Diagnostic cytopathology. Volume 44:Issue 4(2016)
• Page Start: 317
• Page End: 323
• Publication Date: 2016-01-22
• Subjects: intranodal palisaded myofibroblastoma (IPM) -- fine‐needle aspiration cytology (FNAC) -- so called amanthiod fibers -- SMA -- vimentin -- May grumwald giemsa(MGG) -- Hematoxylin & Eosin(H&E); Cytodiagnosis -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Periodicals; 616.07582
• DOI: 10.1002/dc.23407
• Languages: English
• ISSNs: 8755-1039

Abstract

Abstract : Intranodal palisaded myofibroblastoma (IPM) is a benign entity, characterized by intranodal proliferation of cells of myofibroblastic origin. It has five distinct histologic features: compressed remnants of lymphoid tissue at the periphery, spindle cells with nuclear palisading, intralesional hemorrhage, amianthoid fibers, and intracellular and extracellular fuchsinophilic bodies. The spindle cells are SMA and vimentin (IHC) positive and are negative for S 100, and has a low proliferative index. Cytologic diagnosis of this lesion is a diagnostic challenge and has to be differentiated from other stroma rich lesions including schwannoma. The FNA smears were reviewed after histopathology to look for any specific features. This report highlights the variable character of spindle cells, presence of unique "amanthiod fibers" and blood vessel within cell clusters in MGG stained FNA smears, which can be a useful diagnostic clue. This observation is being reported for the first time. Diagn. Cytopathol. 2016;44:317–323. © 2016 Wiley Periodicals, Inc.