Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses. Issue 12 (29th January 2016)

• Record Type: Journal Article
• Authors: Applegate, Matthew B.; Partlow, Benjamin P.; Coburn, Jeannine; Marelli, Benedetto; Pirie, Christopher; Pineda, Roberto; Kaplan, David L.; Omenetto, Fiorenzo G.
• Is Part Of: Advanced materials. Volume 28:Issue 12(2016)
• Page Start: 2417
• Page End: 2420
• Publication Date: 2016-01-29
• Subjects: ocular prosthesis -- photocrosslinking -- silk; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201504527
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A novel method to photocrosslink silk fibroin protein is reported, using riboflavin (vitamin B2) as a photoinitiator and the mechanism of crosslinking is determined. Exposure of riboflavin‐doped liquid silk solution to light results in the formation of a transparent, elastic hydrogel. Several applications for this new material are investigated including corneal reshaping to restore visual acuity and photolithography.