Transition Metal‐Free Approach to Propynenitriles and 3‐Chloropropenenitriles. Issue 6 (8th March 2016)

• Record Type: Journal Article
• Authors: Sharma, Pawan K.; Ram, Sita; Chandak, Navneet
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 6(2016)
• Page Start: 894
• Page End: 899
• Publication Date: 2016-03-08
• Subjects: aqueous ammonia -- chloropropenenitriles -- iodine -- propynenitriles -- transition metal‐free conditions; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201501103
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A transition metal‐free, facile and efficient one‐pot protocol for the synthesis of propynenitriles from readily available 3‐chloropropenals is disclosed. The reaction conditions have also been optimized for the exclusive formation and isolation of 3‐chloropropenenitriles which are important building blocks in general and are intermediates in the synthesis of propynenitriles. The hallmark of the methodology is the use of non‐toxic reagents, milder, metal‐free and economically benign reaction conditions avoiding a harsh dehydration step while achieving excellent yields. Abstract :