Dfcomb: An R-package for phase I/II trials of drug combinations. Issue 125 (March 2016)

• Record Type: Journal Article
• Authors: Riviere, Marie-Karelle; Jourdan, Jacques-Henri; Zohar, Sarah
• Is Part Of: Computer methods and programs in biomedicine. Issue 125(2016)
• Page Start: 117
• Page End: 133
• Publication Date: 2016-03
• Subjects: Dose-finding -- Phase I -- Combination -- Adaptive design -- R package; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2015.10.018
• Languages: English
• ISSNs: 0169-2607

Abstract

Abstract : Highlights: R package "dfcomb" available for phase I combination clinical trials according to previous methodological paper. Implement a single prospective clinical trial or simulation studies of phase I combination trials in oncology. Features and illustration of the functions. Promote the use of innovative adaptive design for early phase combination trials. Abstract: In this paper, we present the dfcomb R package for the implementation of a single prospective clinical trial or simulation studies of phase I combination trials in oncology. The aim is to present the features of the package and to illustrate how to use it in practice though different examples. The use of combination clinical trials is growing, but the implementation of existing model-based methods is complex, so this package should promote the use of innovative adaptive designs for early phases combination trials.