Associations of Systemic Diseases with Intermediate Uveitis. (2nd January 2016)

• Record Type: Journal Article
• Authors: Shoughy, Samir S.; Kozak, Igor; Tabbara, Khalid F.
• Is Part Of: Ophthalmic epidemiology. Volume 23:Number 1(2016)
• Page Start: 27
• Page End: 31
• Publication Date: 2016-01-02
• Subjects: Asthma -- intermediate uveitis -- multiple sclerosis -- tuberculosis -- uveitis; Blindness -- Prevention -- Periodicals; Eye -- Diseases -- Epidemiology -- Periodicals; Ophthalmology -- Periodicals; 614.5997
• DOI: 10.3109/09286586.2015.1119286
• Languages: English
• ISSNs: 0928-6586

Abstract

ABSTRACT: Purpose : To determine the associations of systemic diseases with intermediate uveitis. Methods : The medical records of 50 consecutive cases with intermediate uveitis referred to The Eye Center in Riyadh, Saudi Arabia, were reviewed. Age- and sex-matched patients without uveitis served as controls. Patients had complete ophthalmic and medical examinations. Results : There were 27 male and 23 female patients. Mean age was 29 years with a range of 5–62 years. Overall, 21 cases (42%) had systemic disorders associated with intermediate uveitis and 29 cases (58%) had no associated systemic disease. A total of 11 patients (22%) had asthma, 4 (8%) had multiple sclerosis, 3 (6%) had presumed ocular tuberculosis, 1 (2%) had inflammatory bowel disease, 1 (2%) had non-Hodgkin lymphoma and 1 (2%) had sarcoidosis. Evidence of systemic disease was found in 50 (5%) of the 1, 000 control subjects. Bronchial asthma was found in 37 patients (3.7 %), multiple sclerosis in 9 patients (0.9%), inflammatory bowel disease in 3 patients (0.3%), and tuberculosis in 1 patient (0.1%). None of the control patients had sarcoidosis or lymphoma. There were statistically significant associations between intermediate uveitis and bronchial asthma ( p = 0.0001), multiple sclerosis ( p = 0.003) and tuberculosis ( p = 0.0005). Conclusion : Bronchial asthma and multiple sclerosis were the most frequently encountered systemic diseases associated with intermediate uveitis in our patient population. Patients with intermediate uveitis should undergo careful history-taking and investigations to rule out associated systemic illness.