Hb Matera (HBB: c.167 T > A): A Second Case Detected in a Pregnant Chinese Woman by the Capillary Electrophoresis Method. (3rd March 2016)

• Record Type: Journal Article
• Authors: Li, You-qiong; Ye, Li-Hua; Mo, Yun
• Is Part Of: Hemoglobin. Volume 40:Number 2(2016)
• Page Start: 125
• Page End: 126
• Publication Date: 2016-03-03
• Subjects: Capillary electrophoresis (CE) -- Hb Matera -- high performance liquid chromatography (HPLC) -- thalassemia; Hemoglobinopathy -- Periodicals; Hemoglobin -- Periodicals; Hematology -- Periodicals; Thalassemia -- Periodicals; Blood -- Diseases -- Periodicals; 612.1111
• DOI: 10.3109/03630269.2015.1106411
• Languages: English
• ISSNs: 0363-0269

Abstract

Abstract: Hb Matera ( HBB : c.167 T > A) is an unstable β-globin gene variant with an A T G > A A G substitution at codon 55. Its coelution with Hb A2 on high performance liquid chromatography (HPLC) makes it difficult to discriminate between Hb Matera and Hb E ( HBB : c.79 G > A) that also coelutes with Hb A2 in this method. However, we found that capillary electrophoresis (CE) was able to detect Hb Matera and discriminate it from Hb E, based on the quantification of the peaks and on hematological parameters.