Angiotensin converting enzyme (I/D) gene polymorphism contributes to ischemic stroke risk in Caucasian individuals: a meta-analysis based on 22 case-control studies. (2nd June 2016)

• Record Type: Journal Article
• Authors: Yuan, Hai; Wang, Xiaotong; Xia, Qing; Ge, Pingping; Wang, Xiumin; Cao, Xiaoguang
• Is Part Of: International journal of neuroscience. Volume 126:Number 6(2016:Jun.)
• Page Start: 488
• Page End: 498
• Publication Date: 2016-06-02
• Subjects: angiotensin converting enzyme -- polymorphism -- ischemic stroke -- meta-analysis; Nervous system -- Periodicals; 612.805
• DOI: 10.3109/00207454.2015.1036421
• Languages: English
• ISSNs: 0020-7454

Abstract

Abstract : Background : Stroke is a multifactorial disease in which genetic factors play an important role. Previous studies associated angiotensin converting enzyme (ACE) (insertion/deletion, I/D) gene polymorphism with ischemic stroke risk in Caucasian individuals reported conflicting results. The purpose of this study was to evaluate the association between ACE (I/D) gene polymorphism and ischemic stroke risk by a meta-analysis. Methods: The related studies were searched in MEDLINE, EMBASE and HuGEnet databases. The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for ischemic stroke risk associated with this polymorphism were estimated using fixed-effect or random-effects model. Twenty-two studies (5528/5081 cases/controls) were eligible in our meta-analysis. Results : Overall, statistical associations of the ACE (I/D) polymorphism with ischemic stroke risk were found in dominant model (DD + ID versus II) : OR = 1.21, 95% CI = (1.06, 1.38), P = 0.006, recessive model (DD versus ID + II): OR = 1.28, 95% CI = (1.05, 1.55), P = 0.01, and homozygote comparison (DD versus II): OR = 1.37, 95% CI = (1.14, 1.65), P = 0.001 for Caucasians. When stratifying according to stroke subtypes, there were similarly significant differences for small vessel disease in dominant model (DD + ID versus II) : OR = 1.44, 95% CI = (1.01, 2.05), P = 0.04, recessive model (DD versus ID + II): OR = 1.30, 95% CI = (1.09, 1.55), P = 0.004, and homozygote comparison (DD versus II): OR = 1.44, 95% CI = (1.15, 1.80), P = 0.001. Conclusion : This analysis suggests that the ACE (I/D) polymorphism may be a risk factor for ischemic stroke, genotype DD of ACE could increase the risk of ischemic stroke in Caucasians. Subgroup analyses indicate that stroke subtypes may be a genetic risk factor of ischemic stroke, and there might be a greater genetic liability with small vessel disease.