Endothelial cilia protect against atherosclerosis. (14th January 2016)

• Record Type: Journal Article
• Authors: Schermer, Bernhard; Benzing, Thomas
• Is Part Of: EMBO reports. Volume 17:Number 2(2016:Feb.)
• Page Start: 125
• Page End: 126
• Publication Date: 2016-01-14
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.15252/embr.201541890
• Languages: English
• ISSNs: 1469-221X

Abstract

Abstract : Research over the past 15 years has established that defective primary cilia play a fundamental role in the pathogenesis of various genetic and acquired human diseases now termed ciliopathies. A new study, published in this issue of EMBO reports, expands the spectrum of cilia‐related diseases by uncovering a role for primary cilia in preventing cardiovascular disease. Dinsmore and Reiter show that lack of endothelial cilia in the aorta results in accelerated development of atherosclerotic lesions in a mouse model of atherosclerosis on a high‐fat, high‐cholesterol diet. Loss of endothelial cilia further increases inflammatory gene expression and reduces vasoprotective eNOS activity1 . In summary, this interesting study identifies a role for aortic endothelial cilia to protect against atherosclerosis. Abstract : A study in this issue shows that primary cilia on endothelial cells of the aorta protect a mouse model of artherosclerosis from developing the disease.