Novel regulators of cardiac inflammation: Matricellular proteins expand their repertoire. (February 2016)

• Record Type: Journal Article
• Authors: Rienks, Marieke; Papageorgiou, Anna-Pia
• Is Part Of: Journal of molecular and cellular cardiology. Volume 91(2016:Feb.)
• Page Start: 172
• Page End: 178
• Publication Date: 2016-02
• Subjects: Matrix -- Sterile inflammation -- Myocarditis -- Matricellular proteins; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2016.01.008
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: More than 20 years ago, Paul Bornstein coined the term matricellular protein to describe a group of secreted extracellular matrix proteins with de-adhesive properties. Though this is still true today, this family of proteins is vastly expanding with new emerging functions pushing the boundaries of this classic definition. In the heart, matricellular proteins have been extensively investigated in models of myocardial infarction, pressure overload, viral myocarditis and age-related cardiomyopathy with clear implications during cardiac fibrosis yet their involvement in regulating cardiac inflammation is less established. In this review, we describe our current understanding of the immune activation by damage- or pathogen-associated molecular pattern molecules during cardiac injury making a distinction between sterile versus non-sterile cardiac inflammation, and explain how matricellular proteins influence this crucial pathophysiological response in the heart. Highlights: Injury within the cardiac environment releases damage or pathogen associated molecular pattern molecules The nature of the cardiac immune response is dependent on the type of the cardiac injury Matricellular proteins are novel regulators of cardiac inflammation in addition to their role during cardiac fibrosis.