Origins of cardiac fibroblasts. (February 2016)

• Record Type: Journal Article
• Authors: Moore-Morris, Thomas; Cattaneo, Paola; Puceat, Michel; Evans, Sylvia M.
• Is Part Of: Journal of molecular and cellular cardiology. Volume 91(2016:Feb.)
• Page Start: 1
• Page End: 5
• Publication Date: 2016-02
• Subjects: Fibroblast -- Fibrosis -- Hypertrophy -- Myocardial infarction -- Fibroblast markers -- Cardiac lineage; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2015.12.031
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as heart failure involving fibrosis. Cardiac fibroblasts have long remained a poorly characterized cardiac lineage. Well characterized markers are now paving the way for a better understanding of the roles of these cells in various developmental and disease contexts. Notably, the relevance of processes including endothelial-tomesenchymal transition and the recruitment of circulating fibroblast progenitors in heart failure has been challenged. This review describes the latest findings on cardiac fibroblast markers and developmental origins, and discusses their importance in myocardial remodeling. Effective modulation of cardiac fibroblast activity would likely contribute to successful treatment of various cardiac disorders. Highlights: Recently described robust cardiac fibroblast markers can now be used to identify fibroblasts in healthy and fibrotic heart. Cardiac fibroblasts have diverse developmental origins. Fibrosis results from the expansion of resident fibroblast lineages.