Multifunctional Antioxidants: Regenerable Radical‐Trapping and Hydroperoxide‐Decomposing Ebselenols. (15th February 2016)

• Record Type: Journal Article
• Authors: Kumar, Shailesh; Yan, Jiajie; Poon, Jia‐fei; Singh, Vijay P.; Lu, Xi; Karlsson Ott, Marjam; Engman, Lars; Kumar, Sangit
• Is Part Of: Angewandte Chemie. Volume 128:Number 11(2016)
• Page Start: 3793
• Page End: 3797
• Publication Date: 2016-02-15
• Subjects: Antioxidantien -- Ascorbinsäure -- Ebselen -- Selen -- Zytotoxizität; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201510947
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than α‐tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25 μm, the ebselenol derivatives showed minimal toxicity in pre‐osteoblast MC3T3 cells.