Risk factors and patterns of early recurrence after curative hepatectomy for hepatocellular carcinoma. (March 2016)

• Record Type: Journal Article
• Authors: Hirokawa, Fumitoshi; Hayashi, Michihiro; Asakuma, Mitsuhiro; Shimizu, Tetsunosuke; Inoue, Yoshihiro; Uchiyama, Kazuhisa
• Is Part Of: Surgical oncology. Volume 25:Number 1(2016)
• Page Start: 24
• Page End: 29
• Publication Date: 2016-03
• Subjects: Early recurrence -- Hepatocellular carcinoma -- Indocyanine green retention rate at 15 min -- ICGR15 -- Microvascular invasion -- Treatment strategy; Cancer -- Surgery -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Electronic journals; 616.994059
• DOI: 10.1016/j.suronc.2015.12.002
• Languages: English
• ISSNs: 0960-7404

Abstract

Abstract: Background: Hepatocellular carcinoma (HCC) often recurs after curative hepatectomy; and early recurrence after hepatectomy (ERAH) is associated with poor prognosis. This study aimed to clarify risk factors and disease patterns for ERAH. Methods: We retrospectively analyzed clinicopathological factors of 232 patients who underwent initial curative hepatectomies for HCC between April 2000 and March 2013, and examined associated risk factors and early recurrence patterns by liver function status (as indicated by indocyanine green retention rate at 15 min [ICGR15]). Results: Patients who experienced recurrence within 6 months after hepatectomy (i.e., ERAH) had significantly shorter survival than those with longer disease-free intervals ( P < 0.001). In multivariate analysis, microvascular invasion (mVI; P = 0.034) and ICGR15 ≥ 16% ( P = 0.010) were independent risk factors for ERAH. In the ICGR1<16% subgroup, positive L3-AFP ( P = 0.04), tumor size ≥5 cm ( P = 0.011), surgical margin = 0 ( P = 0.0103), mVI ( P = 0.034), and extrahepatic recurrence were significant predictors of ERAH; in the ICGR15 ≥ 16%, subgroup, multiple tumors ( P = 0.046) were identified as a risk factor for ERAH; however, this group did not experience much extrahepatic recurrence. Conclusions: ERAH was associated with mVI and ICGR15 ≥ 16%. Recurrence patterns and risk factors vary by liver function status, which should be considered in forming management strategies for early recurrence of HCC after curative hepatectomy. Highlights: Early recurrence after hepatectomy for HCC have a poor prognosis. Risk factors of early recurrence were microvascular invasion(mVI) and ICGR15 ≥ 16%. L3-AFP, tumor size, and mVI shown as independent risk factors in the ICGR15 < 16%. The ICGR15 < 16% had a significantly higher rate of extrahepatic recurrence. Multiple tumors were associated with early recurrence and intrahepatic recurrence.