Decoding the RNA structurome. (February 2016)

• Record Type: Journal Article
• Authors: Lu, Zhipeng; Chang, Howard Y
• Is Part Of: Current opinion in structural biology. Volume 36(2016)
• Page Start: 142
• Page End: 148
• Publication Date: 2016-02
• Subjects: Molecular biology -- Periodicals; 570
• DOI: 10.1016/j.sbi.2016.01.007
• Languages: English
• ISSNs: 0959-440X

Abstract

Highlights: RNA structurome is the systematic map of RNA structures across the transcriptome. New technologies enable in vivo view of RNA strucutromes. RNA structurome reveal diverse modes of regulation via RBPs, miRNAs, and RNA modifications. Solving long range and complex RNA structures are future challenges. Abstract : Structures of RNA molecules are essential for their architectural, regulatory, and catalytic functions. Recent advances in high throughput sequencing enabled the development of methods for probing RNA structures on a transcriptome-wide scale — termed the RNA structurome. Here we review the state-of-the-art technologies for probing the RNA structurome, and highlight insights gained from these studies. We also point out the limits of current methods and discuss potential directions for future improvements.