Ophiopogon japonicus—A phytochemical, ethnomedicinal and pharmacological review. (2nd April 2016)

• Record Type: Journal Article
• Authors: Chen, Min-Hui; Chen, Xiao-Jia; Wang, Mei; Lin, Li-Gen; Wang, Yi-Tao
• Is Part Of: Journal of ethnopharmacology. Volume 181(2016)
• Page Start: 193
• Page End: 213
• Publication Date: 2016-04-02
• Subjects: ABTS 2, 2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) -- ADR adverse reaction -- ALT alanine transaminase -- AST aspartate transaminase -- BBMV intestinal brush border membrane vesicles -- CCR5 C-C chemokine receptor type 5 -- DOX Doxorubicin -- DPPH 2, 2-diphenyl-1-picrylhydrazyl -- DTH delayed-type hypersensitivity -- DT-13 ruscogenin 1-O-[β-d-glucopyranosyl-(1→2)]-[β-D-xylopyranosyl-(1→3)]-β-D-fucopyranoside -- ELSD evaporating light scattering detector -- eNOS endothelial nitric oxide synthase -- GSK glycogen synthase kinase -- HDL-C high density lipoprotein cholesterol -- HKCMMS Hong Kong Chinese Materia Medica Standards -- HPLC high performance liquid chromatography -- HUVEC human umbilical vein endothelial cells -- ICAM-1 intercellular adhesion molecule-1 -- IDH intradialytic hypotension -- IFN-γ interferon-γ -- IL interleukin -- iNOS inducible nitric oxide synthase -- InsR insulin receptor -- IRS-1 insulin receptor substrate-1 -- LDL-C low density lipoprotein cholesterol -- LPS lipopolysaccharide -- MCAO middle cerebral artery occlusion -- MMP matrix metalloproteinase -- MNT mouse bone marrow micronucleus test -- MPO myeloperoxidase -- MS mass spectrometry -- NF-κB nuclear factor-κB -- NSCLC non-small cell lung cancer -- OGTT oral glucose tolerance test -- OJL O. japonicus lectin -- OOJ oligosaccharides of O. japonicus -- OPL Ophiopogon polysaccharide liposome -- PCl picryl chloride -- PI3K phosphoinositide 3-kinase -- PMA phorbol-12-myristate-13-acetate -- ROJ-ext 70% ethanol fraction from aqueous extract of O. japonicus root -- ROS reactive oxygen species -- RUS ruscogenin -- SGMI Shengmai injection -- SMC Shengmai capsule -- SMG submandibular gland -- SMI Shenmai injection -- SMS Shengmai San -- SPE solid-phase extraction -- TC total cholesterol -- TCM traditional Chinese medicine -- TF tissue factor -- TG triglycerides -- TNF-α tumor necrosis factor-α -- UV ultraviolet -- VEGF vascular endothelial growth factor; Ophiopogon japonicus -- Phytochemistry -- Quality control -- Ethnopharmacology -- Pharmacology; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2016.01.037
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Ophiopogonis Radix (Maidong in Chinese), the root of Ophiopogon japonicus, is widely used in local medicines of China, Japan and some south-eastern Asian countries. According to the traditional Chinese medicine (TCM) principle, Ophiopogonis Radix nourishes the yin, promotes body fluid production, moistens the lung, eases the mind and clears away heart fire. This review summarizes the achievements of the investigations in botany, phytochemistry, quality control, traditional uses, pharmacological activities and clinical studies on O. japonicus ; this review also describes the shortcomings of studies on this herbal drug and thus serves as the basis of further scientific research and development of this traditional herbal drug. Materials and methods: O. japonicus -related information was collected from various resources, including books on Chinese herbs and the Internet databases, such as Google Scholar, SciFinder, Web of Science, Elsevier, ACS, PubMed and China Knowledge Resource Integrated (CNKI). Results: O. japonicus is widely distributed in East Asia, especially in China. Numerous compounds were identified from this plant. The main components of O. japonicus include steroidal saponins, homoisoflavonoids and polysaccharides, which exhibited various pharmacological activities, such as cardiovascular protection, anti-inflammation, anticancer, anti-oxidation, immunomodulation, cough relief, antimicrobial, and anti-diabetes. Conclusions: O. japonicus is a common traditional Chinese herbal drug used as the main ingredient in many prescriptions. Modern researches verified that O. japonicus can be used either as a healthy food or a therapeutic agent for disease prevention and treatment. The molecular mechanisms and chemical principles of this herbal medicine should be further explored. Graphical abstract: