ChemInform Abstract: Development of a Direct Photocatalytic C—H Fluorination for the Preparative Synthesis of Odanacatib. Issue 13 (March 2016)

• Record Type: Journal Article
• Authors: Halperin, Shira D.; Kwon, Daniel; Holmes, Michael; Regalado, Erik L.; Campeau, Louis‐Charles; DiRocco, Daniel A.; Britton, Robert
• Is Part Of: ChemInform. Volume 47:Issue 13(2016)
• Page Start: no
• Page End: no
• Publication Date: 2016-03
• Subjects: aminocarboxylic acids (hydrazinocarboxylic acids) and esters (acyclic compounds) -- photochemistry, radiation chemistry, chemoluminescence -- halogenation -- continuous flow processes, flow processes, microreactors; Chemistry -- Abstracts -- Periodicals; 540.5
• DOI: 10.1002/chin.201613062
• Languages: English
• ISSNs: 0931-7597

Abstract

Abstract: A one‐step photocatalytic fluorination of (S)‐leucine methyl ester (I) is thoroughly elaborated which allows for the multi‐gram preparation of (S)‐γ‐fluoroleucine methyl ester (II) under continuous flow conditions, thus representing a straightforward access to the critical intermediate (II) of odanacatib (III).