Anisotropic Self‐Assembly of Citrate‐Coated Gold Nanoparticles on Fluidic Liposomes. Issue 12 (23rd February 2016)

• Record Type: Journal Article
• Authors: Sugikawa, Kouta; Kadota, Tatsuya; Yasuhara, Kazuma; Ikeda, Atsushi
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 12(2016)
• Page Start: 4059
• Page End: 4063
• Publication Date: 2016-02-23
• Subjects: gold nanoparticles -- lipid bilayer -- liposomes -- phase transition temperature -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201511785
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The behavior of self‐assembly processes of nanoscale particles on plasma membranes can reveal mechanisms of important biofunctions and/or intractable diseases. Self‐assembly of citrate‐coated gold nanoparticles (cAuNPs) on liposomes was investigated. The adsorbed cAuNPs were initially fixed on the liposome surfaces and did not self‐assemble below the phospholipid phase transition temperature ( T m ). In contrast, anisotropic cAuNP self‐assembly was observed upon heating of the composite above the T m, where the phospholipids became fluid. The number of self‐assembled NPs is conveniently controlled by the initial mixing ratio of cAuNPs and liposomes. Gold nanoparticle protecting agents strongly affected the self‐assembly process on the fluidic membrane. Abstract : Burnt orange peel : Citrate‐coated gold nanoparticles self‐assembled into an anisotropic structure on lipid membranes by heating above the transition temperature of the lipid bilayer. The critical temperature for self‐assembly was determined by lipid components.