An upconversion nanoparticle/Ru(ii) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent. Issue 28 (1st March 2016)

• Record Type: Journal Article
• Authors: Chen, Yumeng; Jiang, Guoyu; Zhou, Qianxiong; Zhang, Yangyang; Li, Ke; Zheng, Yue; Zhang, Baowen; Wang, Xuesong
• Is Part Of: RSC advances. Volume 6:Issue 28(2016)
• Page Start: 23804
• Page End: 23808
• Publication Date: 2016-03-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra03396b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A hybrid system is designed to release a DNA covalent-binding agent upon 980 nm laser irradiation. Abstract : Photoactivated anticancer chemotherapy distinguishes itself by its high selectivity by virtue of the spatiotemporal control of irradiation. However, short photoactivation wavelengths limit its application. Herein, an amphiphilic Ru(ii ) complex, cis -[Ru(bpy)2 (C18 H37 CN)2 ] 2+ (bpy = 2, 2′-bipyridine), was embedded along with a poly(ethylene glycol, PEG)-modified lipid onto the surfaces of oleate-capped lanthanide-doped upconversion nanoparticles (UCNPs). The resultant core–shell hybrid system is water-dispersible, stable in the dark, and releases a DNA covalent-binding agent of [Ru(bpy)2 (H2 O)2 ] 2+ upon 980 nm laser irradiation, providing guidelines for developing near-infrared (NIR) light triggered chemotherapeutics.