Case Report of an Hepatoid Adenocarcinoma of the Stomach. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Gaeta, Raffaele; Ugolini, Clara; Castagna, Maura
• Is Part Of: Applied immunohistochemistry & molecular morphology. Volume 24:Issue 2(2016)
• Publication Date: 2016-02
• Subjects: hepatoid adenocarcinoma -- stomach -- α-fetoprotein; Diagnostic immunohistochemistry -- Periodicals; Immunohistochemistry -- Periodicals; Cells -- Morphology -- Periodicals; Molecular diagnosis -- Periodicals; 616.079
• DOI: 10.1097/PAI.0000000000000286
• Languages: English
• ISSNs: 1541-2016

Abstract

Abstract : Hepatoid adenocarcinoma (HAC) is a rare but important type of extrahepatic tumor that has a morphologic similarity to hepatocellular carcinoma, with production of α-fetoprotein in high amounts and a poor prognosis. Stomach is one of the organs in which HAC has been most commonly identified. We report a case of an old man with a polypoid mass in the prepyloric region. The microscopical aspects were suggestive for an undifferentiated adenocarcinoma, but the positive immunohistochemical staining for α-fetoprotein, α-1-antitrypsin, α-1-antichymotrypsin, and Hep Par1 were crucial for the final diagnosis of hepatoid adenocarcinoma of the stomach. Because of the poor prognosis for this type of tumor, correct and early-stage diagnosis of HAC is essential and long-term follow-up is required.