Automated Flow Injection Chromatography for the Rapid Assay of Parabens in Hygiene Wipes. (23rd March 2016)

• Record Type: Journal Article
• Authors: Kondylis, Panagiotis; Barbatsi, Margarita; Economou, Anastasios
• Is Part Of: Analytical letters. Volume 49:Number 5(2016)
• Page Start: 690
• Page End: 698
• Publication Date: 2016-03-23
• Subjects: Chromatography -- flow injection -- monolithic column -- parabens; Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Abstracts; 543
• DOI: 10.1080/00032719.2015.1017763
• Languages: English
• ISSNs: 0003-2719

Abstract

ABSTRACT: A fully automated flow injection chromatography (FIC) instrument and method are reported for the determination of methylparaben and propylparaben. The system consisted of a computer-controlled MilliGAT precision pump, a six–way injection valve, a peristaltic pump, a monolithic column, and an ultraviolet absorbance detector. The mobile phase composition, flow rate, and sample volume were optimized. The method was fully validated; the calibration plots were linear from 1.0 × 10 −6 to 5.0 × 10 −5 mol L −1 for both parabens. The limits of detection were 1.0 × 10 −7 mol L −1 for methylparaben and 3.0 × 10 −7 mol L −1 for propylparaben. The recoveries for both parabens were 97% and the interlaboratory reproducibility was 2.4% for methylpareben and 4.1% for propylparaben at 1.0 × 10 −5 mol L −1 . The method was employed for the determination of methylparaben and propylparaben in hygiene wipes.