Central regions of keloids are severely ischaemic. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Touchi, Ryoma; Ueda, Koichi; Kurokawa, Norifumi; Tsuji, Motomu
• Is Part Of: Journal of plastic, reconstructive & aesthetic surgery. Volume 69:Issue 2(2016:Feb.)
• Page Start: e35
• Page End: e41
• Publication Date: 2016-02
• Subjects: Keloid -- Ischaemia -- Hypoxia-induced factor 1α -- Vascular endothelial growth factor; Surgery, Plastic -- Great Britain -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Surgery, Plastic -- Great Britain -- Periodicals; 617.9505
• DOI: 10.1016/j.bjps.2015.11.006
• Languages: English
• ISSNs: 1748-6815

Abstract

Summary: We classified scars as keloids, hypertrophic scars and mature scars, and then examined the scars for differences in central and marginal vascularization. We found significant differences in localized hypoxia-induced factor-1α (HIF-1α) expression and vascular density in keloids, but no localized differences in hypertrophic or mature scars. The central areas of keloids exhibited higher HIF-1α expression and lower vascular density than marginal areas, suggesting that the former are severely ischaemic.