Assembly of substituted phenanthridines via a cascade palladium-catalyzed coupling reaction, deprotection and intramolecular cyclization. Issue 23 (17th February 2016)

• Record Type: Journal Article
• Authors: Ge, Jun; Wang, Xiaojian; Liu, Tianqi; Shi, Zeyu; Xiao, Qiong; Yin, Dali
• Is Part Of: RSC advances. Volume 6:Issue 23(2016)
• Page Start: 19571
• Page End: 19575
• Publication Date: 2016-02-17
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra00249h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A practical method for one-pot synthesis of substituted phenanthridines is described. Via this method, a series of substituted phenanthridines are obtained in good yields with remarkable functional groups compatibility. Abstract : The discovery and development of a general method for the one-pot synthesis of substituted phenanthridines is presented. In the presence of Pd(PPh3 )4, accessible precursors undergo a Suzuki cross-coupling reaction with 2-(Boc-amino)benzeneboronic acid pinacol ester and then spontaneously undergo deprotection and intramolecular condensation to form the corresponding phenanthridines in one step. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.