Accurate and sensitive total genomic DNA methylation analysis from sub-nanogram input with embedded SERS nanotags. Issue 17 (4th February 2016)
- Record Type:
- Journal Article
- Title:
- Accurate and sensitive total genomic DNA methylation analysis from sub-nanogram input with embedded SERS nanotags. Issue 17 (4th February 2016)
- Main Title:
- Accurate and sensitive total genomic DNA methylation analysis from sub-nanogram input with embedded SERS nanotags
- Authors:
- Wang, Yuling
Wee, Eugene J. H.
Trau, Matt - Abstract:
- Abstract : Accurate and sensitive total genomic DNA methylation analysis from sub-nanogram input was demonstrated by using embedded SERS nanotags. Abstract : Sensitive and accurate total genomic DNA methylation analysis was demonstrated by surface-enhanced Raman scattering (SERS) via embedded internal SERS nanotags. The assay was sensitive to 0.2 ng input DNA while differentiating as low as 6.25% changes in DNA methylation. The method could also successfully differentiate cells before and after de-methylating drug-treatment and between tumor and normal biopsies.
- Is Part Of:
- Chemical communications. Volume 52:Issue 17(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 17(2016)
- Issue Display:
- Volume 52, Issue 17 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 17
- Issue Sort Value:
- 2016-0052-0017-0000
- Page Start:
- 3560
- Page End:
- 3563
- Publication Date:
- 2016-02-04
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6cc00547k ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 805.xml