Insight into a direct solid–solid transformation: a potential approach for the removal of residual solvents. Issue 10 (8th February 2016)

• Record Type: Journal Article
• Authors: Yang, Pengpeng; Lin, Chenguang; Zhuang, Wei; Wen, Qingshi; Zou, Fengxia; Zhou, Jingwei; Wu, Jinglan; Ying, Hanjie
• Is Part Of: CrystEngComm. Volume 18:Issue 10(2016)
• Page Start: 1699
• Page End: 1704
• Publication Date: 2016-02-08
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c6ce00034g
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : A simple humidity process allows a direct solid–solid transformation from the solvate (methanol trihydrate of cAMPNa) to its hydrate form (pentahydrate). Abstract : Here we report two new crystal forms of adenosine 3′, 5′-cyclic monophosphate sodium and the discovery of the direct solid–solid transformation process from its methanol trihydrate (solvate) to its pentahydrate form (hydrate) that is only mediated by humidity. These findings provide a potential approach for the removal of residual solvents in the manufacturing of pharmaceuticals and food additives.