Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers. Issue 6 (21st January 2016)

• Record Type: Journal Article
• Authors: Nehls, Eric M.; Rosales, Adrianne M.; Anseth, Kristi S.
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 6(2016)
• Page Start: 1035
• Page End: 1039
• Publication Date: 2016-01-21
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb02004b
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Photoresponsive azobenzene–cyclodextrin guest–host chemistry can be used to control the release rate of a small peptide from a PEG hydrogel with light. Abstract : We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleration of the release rate of an entrapped model drug.