Diagnostic value of neutrophil–lymphocyte and albumin–globulin ratios in canine soft tissue sarcoma. (29th December 2015)

• Record Type: Journal Article
• Authors: Macfarlane, L.; Morris, J.; Pratschke, K.; Mellor, D.; Scase, T.; Macfarlane, M.; Mclauchlan, G.
• Is Part Of: Journal of small animal practice. Volume 57:Number 3(2016)
• Page Start: 135
• Page End: 141
• Publication Date: 2015-12-29
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12435
• Languages: English
• ISSNs: 0022-4510

Abstract

Abstract : OBJECTIVE: To investigate the ability of neutrophil‐to‐lymphocyte ratio and albumin‐to‐globulin ratio to differentiate soft tissue sarcoma from benign soft tissue tumours. METHODS: A retrospective study of pretreatment haematology and biochemistry in dogs diagnosed with soft tissue sarcoma or benign soft tissue tumours. The neutrophil‐to‐lymphocyte ratio and albumin‐to‐globulin ratio were compared between the two groups. In dogs diagnosed with soft tissue sarcoma, the relationship of neutrophil‐to‐lymphocyte ratio and albumin‐to‐globulin ratio to histological tumour grade (I to III) was assessed. RESULTS: In the dogs with soft tissue sarcoma (n=22), the neutrophil‐to‐lymphocyte ratio was significantly increased and the albumin‐to‐globulin ratio decreased compared to those with benign soft tissue tumours (n=14). The neutrophil‐to‐lymphocyte ratio and albumin‐to globulin ratio were not useful as predictors of tumour grade in dogs diagnosed with soft tissue sarcoma. CLINICAL SIGNIFICANCE: Pretreatment neutrophil‐to‐lymphocyte ratio and albumin‐to globulin ratio may aid with diagnosis and optimal treatment planning. Further investigation into their prognostic implications is warranted.