Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra‐Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High‐Sensitive PCR System. (18th January 2016)

• Record Type: Journal Article
• Authors: Yoneda, Satoshi; Shiozaki, Arihiro; Yoneda, Noriko; Ito, Mika; Shima, Tomoko; Fukuda, Kaori; Ueno, Tomohiro; Niimi, Hideki; Kitajima, Isao; Kigawa, Mika; Saito, Shigeru
• Is Part Of: American journal of reproductive immunology. Volume 75:Number 4(2016)
• Page Start: 440
• Page End: 450
• Publication Date: 2016-01-18
• Subjects: Amniotic fluid -- antibiotic therapy -- microbes -- PCR -- preterm labor; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12484
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract : Objectives: To examine the efficacy of the use of antibiotics in preterm labor (PTL) with intact membranes, after evaluating intra‐amniotic microbes by our rapid and bacteria‐free polymerase chain reaction (PCR) system. Materials and methods: One hundred and four PTL patients before 32 weeks of gestation were recruited. Until 2012, antibiotics were empirically prescribed based on the clinical severity of PTL. Intra‐amniotic microbes in stored samples were evaluated later by our newly established PCR system, and the efficacy of the use of antibiotics in PTL was evaluated. Results: In the amniotic fluid (AF) microbe‐negative patients ( n = 67), antibiotic therapy significantly shortened the gestation period ( P < 0.0001), whereas in the microbe‐positive patients ( n = 37), appropriate antibiotic therapy (proper antibiotic selection against identified AF microbes) was significantly associated with an increase in gestation period ( P < 0.0001). Conclusion: Appropriate antibiotic therapy in PTL with intact membranes prolonged the gestation period.