Inhibition of Helicobacter pylori and Its Associate Urease by Labdane Diterpenoids Isolated from Andrographis paniculata†. (9th December 2015)

• Record Type: Journal Article
• Authors: Shaikh, Rafik U.; Dawane, Ashwini A.; Pawar, Rajendra P.; Gond, Dhananjay S.; Meshram, Rohan J.; Gacche, Rajesh N.
• Is Part Of: Phytotherapy research. Volume 30:Number 3(2016)
• Page Start: 412
• Page End: 417
• Publication Date: 2015-12-09
• Subjects: Helicobacter pylori -- Andrographis paniculata -- diterpenoids -- urease; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.5542
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : The present study was carried out to evaluate anti‐ Helicobacter pylori and its associated urease activity of labdane diterpenoids isolated from Andrographis paniculata . A molecular docking analysis was performed by using ArgusLab 4.0.1 software. The results obtained indicate that compound A possesses strong inhibition to H. pylori, 28 ± 2.98 (minimum inhibitory concentration, 9 µg/mL), and its urease, 85.54 ± 2.62% (IC50, 20.2 µg/mL). Compounds B, C, and D also showed moderate inhibition to H. pylori and its urease. The obtained results were in agreement with the molecular docking analysis of compounds. The phytochemicals under investigation were found to be promising antibacterial agents. Moreover, the isolated compounds can be considered as a resource for searching novel anti‐ H. pylori agents possessing urease inhibition. Copyright © 2015 John Wiley & Sons, Ltd.