Baicalin Reverses Depressive‐Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy. (17th December 2015)

• Record Type: Journal Article
• Authors: Yu, Hai‐Yang; Yin, Zhu‐Jun; Yang, Shui‐Jin; Ma, Shi‐Ping; Qu, Rong
• Is Part Of: Phytotherapy research. Volume 30:Number 3(2016)
• Page Start: 469
• Page End: 475
• Publication Date: 2015-12-17
• Subjects: baicalin -- Apaf‐1 -- caspase‐9 -- caspase‐3 -- apoptosis -- olfactory bulbectomy; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.5550
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Apoptosis is thought to be involved in neurological disorders including major depression. In this study, we examined whether the polyphenolic compound baicalin could decrease apoptosis in the olfactory bulbectomy (OBX) depression rat model. OBX rats exhibited decreased performance in depression‐like behavioural tests and showed evidence of increased oxidative stress, decreased synaptophysin expression, and hippocampal apoptosis. Treatment with baicalin (20 and 40 mg/kg) significantly reversed all of these changes. Baicalin modulated the levels or activity of malondialdehyde, superoxide dismutase, and glutathione peroxidase and prevented apoptotic protease‐activating factor‐1 expression, effectively suppressing caspase‐mediated apoptosis signalling cascades. Our results demonstrate that baicalin has potent antidepressant activity, likely because of its ability to suppress apoptosis. Copyright © 2015 John Wiley & Sons, Ltd.