Association between uric acid, cancer incidence and mortality in patients with type 2 diabetes: Shanghai diabetes registry study. Issue 3 (2nd November 2015)

• Record Type: Journal Article
• Authors: Deng, Zixuan; Gu, Yunjuan; Hou, Xuhong; Zhang, Lei; Bao, Yuqian; Hu, Cheng; Jia, Weiping
• Is Part Of: Diabetes/metabolism research and reviews. Volume 32:Issue 3(2016:Mar.)
• Page Start: 325
• Page End: 332
• Publication Date: 2015-11-02
• Subjects: uric acid -- type 2 diabetes -- cancer -- Chinese population; Diabetes -- Periodicals; Metabolism -- Periodicals; 616.642
• DOI: 10.1002/dmrr.2724
• Languages: English
• ISSNs: 1520-7552

Abstract

Abstract: Background: An elevated serum uric acid level has often been observed with type 2 diabetes or cancer progression. This study aimed to investigate the association between the serum uric acid, cancer incidence, and mortality in Chinese patients with type 2 diabetes. Methods: A total of 8274 patients with type 2 diabetes from the Shanghai Diabetes Registry (SDR) participated. The follow‐up rate was 85.4%. All subjects were divided into four groups according to the serum uric acid concentration: group 1 (1.0 mg/dL ≤ SUA < 3.0 mg/dL), group 2 (3.0 mg/dL ≤ SUA <5.0 mg/dL), group 3 (5.0 mg/dL ≤ SUA < 7.0 mg/dL), and group 4 (SUA ≥ 7.0 mg/dL). The primary outcome was the first diagnosis of any cancer. The secondary outcome was all‐cause mortality. A Cox proportional hazards model was used to estimate the relative risks of cancer and death. Results: One hundred thirty‐seven men and 115 women had cancer by the end of the study. In women, group 1 had the lowest incidence rate of cancer at 30.3 cases per 10 000 person‐years, followed by group 2 (48.2). The cancer incidence rates in groups 3 (80.4) and 4 (100.8) were significantly higher than in group 2 ( p < 0.05). No significant differences were observed in the incidence of cancer in men ( p = 0.76). The risks of overall mortality and death from cancer were not significantly different among the different serum uric acid groups in either sex ( Pmale = 0.480, Pfemale = 0.075). Conclusion: In Chinese female diabetic patients, the incidence of cancer increased with serum uric acid levels. Copyright © 2015 John Wiley & Sons, Ltd.