Inside Back Cover: A Fluorination/Aryl Migration/Cyclization Cascade for the Metal‐Free Synthesis of Fluoro‐Benzoxazepines (Chem. Eur. J. 11/2016). Issue 11 (2nd February 2016)

• Record Type: Journal Article
• Authors: Ulmer, Anna; Brunner, Christoph; Arnold, Andreas M.; Pöthig, Alexander; Gulder, Tanja
• Is Part Of: Chemistry. Volume 22:Issue 11(2016)
• Page Start: 3891
• Page End: 3891
• Publication Date: 2016-02-02
• Subjects: 1, 2-aryl shift -- benzoxazepines -- fluorination -- hypervalent iodine; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201600133
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The search for efficient fluorination methods, which ideally help to unlock new reactivities, is fueled by the importance of fluorinated molecules. With the bench‐stable F‐benziodoxole a new reagent has been established that reveals unexpected fluorination chemistry. Exemplified by the treatment of o ‐amide styrenes with the iodane, a new class of F‐benzoxazepines became available furnished by a fluorination/migration/cyclization cascade. The chemoselective generation of these F‐heterocycles is in clear contrast to the products obtained with the common F‐reagents. More information can be found in the Communication by T. Gulder et al.page 3660 ff.