Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Issue 11 (29th February 2016)

• Record Type: Journal Article
• Authors: Chalmers, Benjamin A.; Xing, Hui; Houston, Sevan; Clark, Charlotte; Ghassabian, Sussan; Kuo, Andy; Cao, Benjamin; Reitsma, Andrea; Murray, Cody‐Ellen P.; Stok, Jeanette E.; Boyle, Glen M.; Pierce, Carly J.; Littler, Stuart W.; Winkler, David A.; Bernhardt, Paul V.; Pasay, Cielo; De Voss, James J.; McCarthy, James; Parsons, Peter G.; Walter, Gimme H.; Smith, Maree T.; Cooper, Helen M.; Nilsson, Susan K.; Tsanaktsidis, John; Savage, G. Paul; Williams, Craig M.
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 11(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-02-29
• Subjects: agrochemicals -- bioisosteres -- cubane -- pharmaceuticals -- structure–activity relationships; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201681161
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Bioisosteres In their Communication onpage 3580 ff., C. M. Williams, G. P. Savage, J. Tsanaktsidis et al. confirm that cubane can act as a benzene bioisostere by synthesizing and evaluating cubane derivatives of five biologically important molecules.