Cover Picture: An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl‐Mediated in situ Activation of α, β‐Unsaturated Carboxylic Acids (Chem. Asian J. 5/2016). Issue 5 (18th February 2016)

• Record Type: Journal Article
• Authors: Que, Yonglei; Lu, Yinan; Wang, Wenjing; Wang, Yuhong; Wang, Haotian; Yu, Chenxia; Li, Tuanjie; Wang, Xiang‐Shan; Shen, Shide; Yao, Changsheng
• Is Part Of: Chemistry, an Asian journal. Volume 11:Issue 5(2016)
• Page Start: 626
• Page End: 626
• Publication Date: 2016-02-18
• Subjects: asymmetric synthesis -- carbenes -- carboxylic acids -- dihydropyranones -- enantioselectivity; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201600174
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract : An efficient assembly of dihydropyranone was realized via the in situ activation of α, β‐unsaturated carboxylic acid and the subsequent formal [3+3] reaction with 1, 3‐dicarbonyl compound synergistically mediated by N‐heterocyclic carbene and LiCl. The ready availability and high stability of the starting materials, good yields, and excellent enantioselectivity make this protocol greatly attractive in the chemistry community. More information can be found in the Communication by Changsheng Yao et al. onpage 678 in Issue 5, 2016 (DOI:10.1002/asia.201501353 ).