One-dimensional collective migration of a proliferating cell monolayer. Issue 8 (22nd January 2016)

• Record Type: Journal Article
• Authors: Recho, Pierre; Ranft, Jonas; Marcq, Philippe
• Is Part Of: Soft matter. Volume 12:Issue 8(2016)
• Page Start: 2381
• Page End: 2391
• Publication Date: 2016-01-22
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/c5sm02857d
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : Motivated by recent experiments on the expansion of highly cohesive cell sheets, our model of collective cell migration in one spatial dimension shows that constant front velocity results from the combined mechanical effects of bulk cell proliferation and front lamellipodial activity. Abstract : The importance of collective cellular migration during embryogenesis and tissue repair asks for a sound understanding of underlying principles and mechanisms. Here, we address recent in vitro experiments on cell monolayers, which show that the advancement of the leading edge relies on cell proliferation and protrusive activity at the tissue margin. Within a simple viscoelastic mechanical model amenable to detailed analysis, we identify a key parameter responsible for tissue expansion, and we determine the dependence of the monolayer velocity as a function of measurable rheological parameters. Our results allow us to discuss the effects of pharmacological perturbations on the observed tissue dynamics.