Multicolor nanoprobes based on silica-coated gadolinium oxide nanoparticles with highly reduced toxicity. Issue 24 (16th February 2016)

• Record Type: Journal Article
• Authors: Atabaev, Timur Sh.; Lee, Jong Ho; Han, Dong-Wook; Choo, Ki Seok; Jeon, Ung Bae; Hwang, Jae Yeon; Yeom, Jeong A.; Kang, ChulHee; Kim, Hyung-Kook; Hwang, Yoon-Hwae
• Is Part Of: RSC advances. Volume 6:Issue 24(2016)
• Page Start: 19758
• Page End: 19762
• Publication Date: 2016-02-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra27685c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Multicolor core-shell nanoprobes were developed for molecular imaging of living cells using optical and MRI technique. Abstract : In recent years, multimodal contrast agents have attracted considerable attention in biomedical imaging. This paper reports the development of a multimodal nanoprobe based on silica-coated gadolinium oxide nanoparticles (NPs) for T 1 -enhanced magnetic resonance (MR) and multicolor optical imaging. MR relaxivity measurements showed that these core–shell NPs could generate strong positive contrast enhancement in T 1 -weighted MR imaging (MRI). Owing to the nominally co-doped Eu 3+ and Tb 3+ ions in the Gd2 O3 host, the synthesized nanoprobes could simultaneously emit blue, green and red fluorescence signals. Furthermore, the cytotoxicity results showed that a thin silica coating on the surface of gadolinium oxide NPs could increase the biocompatibility of the fabricated nanoprobes considerably. The excellent multicolor fluorescence and MRI functionalities of these nanoprobes could have potential biomedical applications.