A porous CuO nanowire-based signal amplification immunosensor for the detection of carcinoembryonic antigens. Issue 21 (9th February 2016)

• Record Type: Journal Article
• Authors: Feng, Taotao; Qiao, Xiuwen; Wang, Haining; Sun, Zhao; Qi, Yu; Hong, Chenglin
• Is Part Of: RSC advances. Volume 6:Issue 21(2016)
• Page Start: 16982
• Page End: 16987
• Publication Date: 2016-02-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra26828a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel electrochemical immunosensor was developed for the detection of CEA based on CNTs–AuNPs as a platform and pCuOw@Fc as labels. The immunosensor showed enhanced electrochemical performance toward the detection of CEA. Abstract : A novel electrochemical immunosensor was developed for carcinoembryonic antigens (CEA) based on gold nanoparticle load carbon nanotubes (CNTs–AuNPs) as an immunosensor platform and porous CuO nanowire supported ferrocene (pCuOw@Fc) as signal amplification labels. The pCuOw were prepared by a simple decomposition of the Cu(OH)2 precursor. The products were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The electrochemical performance of the resulting immunosensor was investigated by cyclic voltammetry (CV), and the electrochemical immunosensor showed enhanced electrochemical performance toward the detection of CEA with a range from 0.005 ng mL −1 to 80 ng mL −1 and a detection limit of 0.0008 ng mL −1 (S/N = 3). The proposed immunosensor was successfully used in determining the CEA in real samples and holds great potential for the sensitive electrochemical biosensing of other analytes.